Sinha Research Lab

Sharmistha Sinha
Sharmistha is a Senior Scientist at the Chemical Biology Unit, Institute of Nano Science and Technology, Department of Science and Technology, Mohali, India. Her research focuses on exploring active and functional protein assemblies in prokaryotes and eukaryotes.
Recent Articles
-
Innate and engineered attributes of bacterial microcompartments for applications in bio-materials science SM Rose, A Radhakrishnan, S Sinha, Journal of Materials Chemistry. B, 4842-4854 2023.
-
Self-assembly of shell protein and native enzyme in a crowded environment leads to catalytically active phase condensates, G Kumar, S Sinha, Biochemical Journal 480 (8), 539-553, 2023.
-
Disordered regions endow structural flexibility to shell proteins and function towards shell–enzyme interactions in 1, 2-propanediol utilization microcompartment G Kumar, JP Hazra, S Sinha Journal of Biomolecular Structure and Dynamics, 1-11 1 2022
-
Barrier-free liquid condensates of nanocatalysts as effective concentrators of catalysis S Bedi, G Kumar, SM Rose, S Rakshit, S Sharmistha. Chem. Commun., 2022
-
A major shell protein of 1, 2‐propanediol utilization microcompartment conserves the activity of its signature enzyme at higher temperature G Kumar, NK Bari, JP Hazra, S Sinha ChemBioChem 23 (9), e2021006942 2022
-
Doxorubicin induced aggregation of α-synuclein: Insights into the mechanism of drug induced Parkinsonism A Garg, S Sinha Colloids and Surfaces B: Biointerfaces 212, 112371 2022
-
Varying protein architectures in 3-dimensions for scaffolding and modulating properties of catalytic gold nanoparticles S Kaur, NK Bari, S Sinha Amino Acids 54 (3), 441-4542 2022
-
Light-controlled shape-changing azomacrocycles exhibiting reversible modulation of pyrene fluorescence emission A Srivastava, S Grewal, NK Bari, M Saraswat, S Sinha, S Venkataramani Organic & Biomolecular Chemistry 20 (26), 5284-52923 2022
-
Naturally occurring protein nano compartments: basic structure, function, and genetic engineering D Goel, S Sinha Nano Express 2 (4), 0420012 2021
-
Factors deciding the assembly and thermostability of the DmrB cage A Garg, S Sinha International Journal of Biological Macromolecules 182, 959-9671 2021
-
Biophysical approaches to understand and re-purpose bacterial microcompartments G Kumar, S Sinha Current Opinion in Microbiology 63, 43-516 2021
-
Protein morphology drives the structure and catalytic activity of bio-inorganic hybrids H Kaur, NK Bari, A Garg, S Sinha International Journal of Biological Macromolecules 176, 106-11616 2021
-
Role of Glycosylation and Oligomerization on the Stability of Soybean Agglutinin S Sinha 2021
-
Doxorubicin induces Aberrant Self-Assembly of P53 by Phase Separation A Garg, S Sinha Biophysical Journal 120 (3), 28a1 2021
-
Probe into a multi-protein prokaryotic organelle using thermal scanning assay reveals distinct properties of the core and the shell NK Bari, JP Hazra, G Kumar, S Kaur, S Sinha Biochimica et Biophysica Acta (BBA)-General Subjects 1864 (10), 129680 7 2020
-
New insights into nCOVID-19 binding domain and its cellular receptors A Garg, G Kumar, S Sinha bioRxiv, 2020.09. 06.285023 2020
-
An Envelope Protein of a Prokaryotic Organelle Function towards Conserving Catalytic Activity of the Native Enzyme at Higher TemperaturesG Kumar, NK Bari, JP Hazra, S Sinha bioRxiv, 2020.02. 18.954511 2020
-
Variable mutations at the p53-R273 oncogenic hotspot position leads to altered properties A Garg, JP Hazra, MK Sannigrahi, S Rakshit, S Sinha Biophysical journal 118 (3), 720-728 132020
-
Temporal control in tritylation reactions through light-driven variation in chloride ion binding catalysis–a proof of concept S Grewal, S Roy, H Kumar, M Saraswat, NK Bari, S Sinha, ... Catalysis Science & Technology 10 (20), 7027-70338 2020
-
Functional protein shells fabricated from the self-assembling protein sheets of prokaryotic organelles NK Bari, G Kumar, JP Hazra, S Kaur, S Sinha Journal of Materials Chemistry B 8 (3), 523-5331 12020
-
Nanoparticle fabrication on bacterial microcompartment surface for the development of hybrid enzyme-inorganic catalyst NK Bari, G Kumar, A Bhatt, JP Hazra, A Garg, ME Ali, S Sinha ACS Catalysis 8 (9), 7742-774821 2018
-
Cellulose-metallothionein matrix for metal binding NK Bari, S Barua, A Garg, MK Sannigrahi, S Sinha Carbohydrate polymers 192, 126-134 8 2018
-
The Wrappers of the 1, 2-Propanediol Utilization Bacterial Microcompartments NK Bari, G Kumar, S Sinha Biochemical and Biophysical Roles of Cell Surface Molecules, 333-3441 2018