Publications

• Bile Acids as Modulators of α-Synuclein Aggregation: Implications for Parkinson’s Therapy H Kaur, D Swadia, S Sinha. ACS Chemical Neuroscience, 2024.  

• Substrate-induced phase transition within liquid condensates reverses the catalytic activity of nanoparticles SM Rose, S Bedi, S Rakshit, S Sinha. Nanoscale, 16(31):14730-3, 2024.

• Innate and engineered attributes of bacterial microcompartments for applications in bio-materials science SM Rose, A Radhakrishnan, S Sinha, Journal of Materials Chemistry B, 4842-4854, 2023.

• Self-assembly of shell protein and native enzyme in a crowded environment leads to catalytically active phase condensates G Kumar, S Sinha, Biochemical Journal 480 (8): 539-553, 2023.

• Disordered regions endow structural flexibility to shell proteins and function towards shell–enzyme interactions in 1, 2-propanediol utilization microcompartment G Kumar, JP Hazra, S Sinha Journal of Biomolecular Structure and Dynamics, 1: 1-11, 2022.

• Barrier-free liquid condensates of nanocatalysts as effective concentrators of catalysis S Bedi, G Kumar, SM Rose, S Rakshit, S Sinha. Chemical Communication, 58 (62): 8634-8637, 2022.

• A major shell protein of 1, 2‐propanediol utilization microcompartment conserves the activity of its signature enzyme at higher temperature G Kumar, NK Bari, JP Hazra, S Sinha ChemBioChem 23 (9), e2021006942 2022

• Doxorubicin induced aggregation of α-synuclein: Insights into the mechanism of drug induced Parkinsonism A Garg, S Sinha Colloids and Surfaces B: Biointerfaces 212, 112371 2022.

• Varying protein architectures in 3-dimensions for scaffolding and modulating properties of catalytic gold nanoparticles S Kaur, NK Bari, S Sinha Amino Acids 54 (3): 441-4542 2022.

• Light-controlled shape-changing azomacrocycles exhibiting reversible modulation of pyrene fluorescence emission A Srivastava, S Grewal, NK Bari, M Saraswat, S Sinha, S Venkataramani Organic & Biomolecular Chemistry 20 (26), 5284-52923 2022.

• Naturally occurring protein nano compartments: basic structure, function, and genetic engineering D Goel, S Sinha Nano Express 2 (4), 0420012 2021.

• Factors deciding the assembly and thermostability of the DmrB cage A Garg, S Sinha International Journal of Biological Macromolecules 182, 959-9671 2021.

• Biophysical approaches to understand and re-purpose bacterial microcompartments G Kumar, S Sinha Current Opinion in Microbiology 63, 43-516 2021.

• Protein morphology drives the structure and catalytic activity of bio-inorganic hybrids H Kaur, NK Bari, A Garg, S Sinha International Journal of Biological Macromolecules 176, 106-11616 2021.

• Role of Glycosylation and Oligomerization on the Stability of Soybean Agglutinin S Sinha 2021.

• Doxorubicin induces Aberrant Self-Assembly of P53 by Phase Separation A Garg, S Sinha Biophysical Journal 120 (3), 28a1 2021.

• Probe into a multi-protein prokaryotic organelle using thermal scanning assay reveals distinct properties of the core and the shell NK Bari, JP Hazra, G Kumar, S Kaur, S Sinha Biochimica et Biophysica Acta (BBA)-General Subjects 1864 (10), 129680 7 2020.

• New insights into nCOVID-19 binding domain and its cellular receptors A Garg, G Kumar, S Sinha bioRxiv, 2020.09. 06.285023 2020

• An Envelope Protein of a Prokaryotic Organelle Function towards Conserving Catalytic Activity of the Native Enzyme at Higher TemperaturesG Kumar, NK Bari, JP Hazra, S Sinha bioRxiv, 2020.02. 18.954511 2020

• Variable mutations at the p53-R273 oncogenic hotspot position leads to altered properties A Garg, JP Hazra, MK Sannigrahi, S Rakshit, S Sinha Biophysical journal 118 (3), 720-728 132020

• Temporal control in tritylation reactions through light-driven variation in chloride ion binding catalysis–a proof of concept S Grewal, S Roy, H Kumar, M Saraswat, NK Bari, S Sinha, ... Catalysis Science & Technology 10 (20), 7027-70338 2020

• Functional protein shells fabricated from the self-assembling protein sheets of prokaryotic organelles NK Bari, G Kumar, JP Hazra, S Kaur, S Sinha Journal of Materials Chemistry B 8 (3), 523-5331 12020

• Nanoparticle fabrication on bacterial microcompartment surface for the development of hybrid enzyme-inorganic catalyst NK Bari, G Kumar, A Bhatt, JP Hazra, A Garg, ME Ali, S Sinha ACS Catalysis 8 (9), 7742-774821 2018

• Cellulose-metallothionein matrix for metal binding NK Bari, S Barua, A Garg, MK Sannigrahi, S Sinha Carbohydrate polymers 192, 126-134 8 2018

• The Wrappers of the 1, 2-Propanediol Utilization Bacterial Microcompartments NK Bari, G Kumar, S Sinha Biochemical and Biophysical Roles of Cell Surface Molecules, 333-3441 2018

• Enhanced bacterial cellulose production from Gluconobacter xylinus using super optimal broth PT Chandrasekaran, NK Bari, S Sinha Cellulose 24, 4367-438127 2017

• Molecular tweezers for the treatment of alzheimer's disease G Bitan, A Shanmugam, A Lomakin, T Schrader, FG Klarner, P Talbiersky, ...2017

• Modulators of amyloid β-protein (Aβ) self-assembly F Rahimi, H Li, S Sinha, G Bitan Developing Therapeutics for Alzheimer's Disease, 97-19114 2016

• Selective molecular transport through the protein shell of a bacterial microcompartment organelle C Chowdhury, S Chun, A Pang, MR Sawaya, S Sinha, TO Yeates, ... Proceedings of the National Academy of Sciences 112 (10), 2990-2995132 2015

• Diverse bacterial microcompartment organelles C Chowdhury, S Sinha, S Chun, TO Yeates, TA Bobik Microbiology and Molecular Biology Reviews 78 (3), 438-468204 2014

• Molecular tweezers for the treatment of amyloid-related diseases G Bitan, A Shanmugam, A Lomakin, T Schrader, FG Klarner, P Talbiersky, ...US Patent 8,791,0925 2014

• Alanine scanning mutagenesis identifies an asparagine–arginine–lysine triad essential to assembly of the shell of the Pdu microcompartment S Sinha, S Cheng, YW Sung, DE McNamara, MR Sawaya, TO Yeates, ...Journal of molecular biology 426 (12), 2328-2345 642014

• Compounds for the treatment of diseases related to protein misfolding T Schrader, K Hochdörffer, J März-Berberich, L Nagel-Steger, G Bitan, ...US Patent 8,481,494 2013

• The PduQ Enzyme Is an Alcohol Dehydrogenase Used to Recycle NAD+ Internally within the Pdu Microcompartment of Salmonella enterica

• S Cheng, C Fan, S Sinha, TA Bobik Public Library of Science 7 (10), e47144 81 2012

• Interactions between the termini of lumen enzymes and shell proteins mediate enzyme encapsulation into bacterial microcompartments

• C Fan, S Cheng, S Sinha, TA Bobik Proceedings of the National Academy of Sciences 109 (37), 14995-15000139 2012

• A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity S Sinha, DHJ Lopes, G Bitan

• ACS Chemical Neuroscience 3 (6), 473-481128 2012

• Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01 S Sinha, Z Du, P Maiti, FG Klärner, T Schrader, C Wang, G Bitan ACS chemical neuroscience 3 (6), 451-458 134 2012

• The PduM Protein Is a Structural Component of the Microcompartments Involved in Coenzyme B12-Dependent 1,2-Propanediol Degradation by Salmonella enterica S Sinha, S Cheng, C Fan, TA Bobik Journal of bacteriology 194 (8), 1912-1918 70 2012

• A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo S Prabhudesai, S Sinha, A Attar, A Kotagiri, AG Fitzmaurice, ... Neurotherapeutics 9, 464-476 175 2012

• Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins DHJ Lopes, S Sinha, C Rosensweig, G Bitan Amyloid Proteins: Methods and Protocols, 11-21 15 2012

• Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins S Sinha, DHJ Lopes, Z Du, ES Pang, A Shanmugam, A Lomakin, ...Journal of the American Chemical Society 133 (42), 16958-16969 3172011 P2‐478:

• A key role for lysine residues in amyloid‐β protein folding, assembly, and toxicity D Lopes, S Sinha, G Bitan Alzheimer's & Dementia 7, S465-S466 1 2011

• Rational Design of β-Sheet Ligands Against Aβ42-Induced Toxicity K Hochdörffer, J März-Berberich, L Nagel-Steger, M Epple, ...Journal of the American Chemical Society 133 (12), 4348-4358 69 2011

• Genetic Analysis of the Protein Shell of the Microcompartments Involved in Coenzyme B12-Dependent 1,2-Propanediol Degradation by Salmonella S Cheng, S Sinha, C Fan, Y Liu, TA Bobik Journal of bacteriology 193 (6), 1385-1392 99 2011

• A Small-Molecule Inhibitor of alpha-Synuclein Neurotoxicity S Prabhudesai, S Sinha, G Bitan, AK Kotagiri, JM Bronstein ANNALS OF NEUROLOGY 68 (4), S63-S63 2010

• Amyloids and protein aggregation–analytical methods H Li, F Rahimi, S Sinha, P Maiti, G Bitan, K Murakami Encyclopedia of analytical chemistry, 1-32 66 2009

• Interactions of aromatic mannosyl disulfide derivatives with Concanavalin A: synthesis, thermodynamic and NMR spectroscopy studies BN Murthy, S Sinha, A Surolia, N Jayaraman, L Szilágyi, I Szabó, ... Carbohydrate research 344 (13), 1758-1763 26 2009

• Probing into the role of conserved N-glycosylation sites in the Tyrosinase glycoprotein family G Gupta, S Sinha, N Mitra, A Surolia

• Glycoconjugate journal 26, 691-695 22 2009

• Concurrence of Danish dementia and cataract: insights from the interactions of dementia associated peptides with eye lens α-crystallin I Surolia, S Sinha, DP Sarkar, PY Reddy, GB Reddy, A Surolia PloS one 3 (8), e2927 11 2008

• Unfolding energetics and stability of banana lectin G Gupta, S Sinha, A Surolia Proteins: Structure, Function, and Bioinformatics 72 (2), 754 760 16 2008

• Form and dimensions of aggregates dictate cytotoxicities of Danish dementia peptides I Surolia, DP Sarkar, S Sinha Biochemical and biophysical research communications 372 (1), 62-66 9 2008

• Fibrillogenesis in ADan peptides is inhibited by biphenyl ethers I Surolia, M Chhibber, DP Sarkar, S Sinha Biochemical and biophysical research communications 370 (4), 681-686 1 2008

• SPR and ITC determination of the kinetics and the thermodynamics of bivalent versus monovalent sugar ligand–lectin interactions BN Murthy, S Sinha, A Surolia, SS Indi, N Jayaraman Glycoconjugate journal 25, 313-321 39 2008

• Deuterium oxide stabilizes conformation of tubulin: a biophysical and biochemical study A Das, S Sinha, BR Acharya, P Paul, B Bhattacharyya, G Chakrabarti BMB reports 41 (1), 62-67 17 2008

• Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates S Gupta, M Chhibber, S Sinha, A Surolia Journal of medicinal chemistry 50 (23), 5589-5599 32 2007

• Subunit assembly of plant lectins S Sinha, G Gupta, M Vijayan, A Surolia Current opinion in structural biology 17 (5), 498-505 68 2007

• Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein: Role of the 4′‐phosphopantetheine group in the stability of the holo … R Modak, S Sinha, N Surolia The FEBS Journal 274 (13), 3313-3326 13 2007

• Napin from Brassica juncea: Thermodynamic and structural analysis of stability TC Jyothi, S Sinha, SA Singh, A Surolia, AGA Rao Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1774 (7), 907-919 28 2007

• Sugar− quantum dot conjugates for a selective and sensitive detection of lectins P Babu, S Sinha, A Surolia Bioconjugate chemistry 18 (1), 146-151 141 2007

• Conformational stability and thermodynamic characterization of homotetrameric Plasmodium falciparum β‐ketoacyl‐ACP reductase K Karmodiya, S Sajad, S Sinha, K Maity, K Suguna, N Surolia IUBMB life 59 (7), 441-449 32 007

• Attributes of glycosylation in the establishment of the unfolding pathway of soybean agglutinin S Sinha, A Surolia Biophysical journal 92 (1), 208-216 38 2007

• Isothermal titration calorimetric study defines the substrate binding residues of calreticulin J Gopalakrishnapai, G Gupta, T Karthikeyan, S Sinha, E Kandiah, ...Biochemical and biophysical research communications 351 (1), 14-20 29 2006

• Hierarchy and the mechanism of fibril formation in ADan peptides I Surolia, GB Reddy, S Sinha Journal of neurochemistry 99 (2), 537-548 21 2006

• Thermodynamic analysis of three state denaturation of Peanut Agglutinin S Dev, DK Nirmala, S Sinha, A Surolia IUBMB life 58 (9), 549-555 17 2006

• Broad substrate stereospecificity of the Mycobacterium tuberculosis 7-keto-8-aminopelargonic acid synthase: spectroscopic and kinetic studies VM Bhor, S Dev, GR Vasanthakumar, P Kumar, S Sinha, A Surolia Journal of Biological Chemistry 281 (35), 25076-25088 26 2006

• N-linked oligosaccharides as outfitters for glycoprotein folding, form and function N Mitra, S Sinha, TNC Ramya, A Surolia Trends in biochemical sciences 31 (3), 156-163 368 2006

• Structural basis for the specificity of basic winged bean lectin for the Tn-antigen: a crystallographic, thermodynamic and modelling study KA Kulkarni, S Sinha, S Katiyar, A Surolia, M Vijayan, K Suguna FEBS letters 579 (30), 6775-6780 40 2005

• Analysis of the peanut agglutinin molten globule-like intermediate by limited proteolysis N Mitra, S Sinha, RM Kini, A Surolia Biochimica et Biophysica Acta (BBA)-General Subjects 1725 (3), 283-289 8 2005

• Insights into hydrophobicity and the chaperone-like function of αA-and αB-crystallins: An isothermal titration calorimetric study MS Kumar, M Kapoor, S Sinha, GB Reddy Journal of Biological Chemistry 280 (23), 21726-21730 80 2005

• Oligomerization endows enormous stability to soybean agglutinin: a comparison of the stability of monomer and tetramer of soybean agglutinin S Sinha, A Surolia Biophysical Journal 88 (6), 4243-4251 49 2005

• Unfolding studies on soybean agglutinin and concanavalin a tetramers: a comparative account S Sinha, N Mitra, G Kumar, K Bajaj, A Surolia Biophysical journal 88 (2), 1300-1310